NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT
Introduction to Week 6 Picks
It's time for Week 6 of the NFL season. This piece explores some plus-money NFL picks. Last week, our NFL bold predictions went 2-1 and came out +1.17 units overall. Since the start of Week 3, picks in this story are up 2.16 units.
Week 6 Predictions
Here are 3 bold predictions for this week in the NFL:
- Fading the Colts offense, despite their strong performance, as they are currently averaging 3.39 points per drive, which would be the most this century if maintained all season long.
Indianapolis is currently averaging 3.39 points per drive. That would be by far the most this century if the Colts are able to keep up this pace all season long.
Author's summary: Explore 3 plus-money NFL bets for Week 6.