Long-term Melatonin Use May Pose Health Risks
A recent study analyzed five years of health data from over 130,000 adults with insomnia who used melatonin supplements for at least a year. The findings indicated a greater likelihood of being diagnosed with heart failure, needing hospitalization for the condition, and dying from any cause in those with chronic insomnia.
Study Presentation
The preliminary results will be presented at the American Heart Association’s Scientific Sessions 2025, held in New Orleans from November 7 to 10. This event is a leading global forum for sharing advances and clinical updates in cardiovascular science.
About Melatonin
Melatonin is a hormone produced naturally by the pineal gland that plays a key role in regulating the sleep-wake cycle. Levels rise in darkness and fall during daylight. Synthetic melatonin supplements, identical in structure to the natural hormone, are commonly used to treat insomnia and jet lag.
Supplement Availability and Regulation
- Melatonin supplements are widely available over the counter in many countries, including the United States.
- In the U.S., these supplements do not require government approval for quality or consistency, so their strength and purity vary by brand.
“Long-term use of melatonin supplements was associated with a higher risk of heart failure diagnosis, heart failure hospitalization and death from any cause in chronic insomnia,” the study summary states.
This research highlights potential risks linked to extended melatonin supplement use among people with insomnia, urging caution in their prolonged consumption.
Author's summary: Extended melatonin use for insomnia may increase heart failure risks and mortality, emphasizing the importance of careful use and monitoring.