Heart Health: Long-Term Melatonin Use Linked to Cardiovascular Risk

Heart Health and Long-Term Melatonin Use

Recent research indicates that individuals with insomnia who take melatonin supplements for over a year may face an increased risk of heart failure compared to those who do not use the sleep aid.

Study Findings

The study found that long-term melatonin users were more likely to:

This research was presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans, though it has not yet been published in a peer-reviewed journal.

Limitations and Concerns

The researchers emphasized that their findings do not prove a direct cause-and-effect link between melatonin supplementation and heart failure risk.

Nevertheless, they highlighted that the results raise important safety concerns regarding long-term melatonin use and suggest the need for further cardiovascular safety studies.

Regulation and Public Use

Many melatonin supplements are available over-the-counter without a prescription, leading to unregulated use without medical supervision.

“Melatonin supplements may not be as harmless as commonly assumed.”
Author's Summary

Long-term melatonin use may pose cardiovascular risks, underscoring the need for more research and cautious use under medical guidance.

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Healthline Healthline — 2025-11-05