Hidden Heart Risks in Long-Term Melatonin Use
Prolonged use of melatonin for sleep issues may carry unforeseen heart dangers. Research shows that chronic melatonin users have nearly double the risk of death and a 3.5 times higher chance of hospitalization due to heart failure.
Study Findings on Heart Failure and Melatonin
A preliminary study presented at the American Heart Association's (AHA) Scientific Sessions 2025 revealed adults with chronic insomnia who took melatonin for a year or more were more likely to develop heart failure, require hospitalization for it, and die from any cause compared to those who did not use the supplement.
This research will be featured at the AHA's annual meeting held November 7–10 in New Orleans, a prominent global event for cardiovascular science and clinical research.
Understanding Melatonin and Its Use
Melatonin is a hormone produced by the pineal gland that controls the body's sleep-wake rhythm, increasing at night and decreasing during the day. Synthetic melatonin, identical to the natural hormone, is commonly used to treat insomnia and jet lag.
- Available over the counter in many countries including the U.S.
- Not FDA-regulated in the U.S., leading to variability in purity and dosage across products
Experts now advise caution with extended melatonin use despite its popular perception as harmless.
Long-term melatonin supplementation for sleep improvement may involve serious cardiovascular risks that were previously underrecognized.
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