Common Supplement Shows Concerning Link to Heart Failure

Research Highlights Potential Risks of Long-Term Melatonin Use

New research has raised concerns about the long-term use of melatonin, a common sleeping aid. An analysis involving over 130,000 adults with insomnia, spanning multiple countries, found that individuals prescribed melatonin for more than one year had significantly higher heart risks.

Key Findings

Context and Cautions

These findings are preliminary and have not yet undergone peer review. They do not definitively prove that melatonin causes these health problems. Instead, they highlight a need for further investigation into the safety of extended melatonin use.

"The results suggest longer-term uses of melatonin need to be studied further to ensure they are safe."

Melatonin is generally considered safe and well-tolerated for short-term use, typically up to 1 to 2 months, especially for adults who are not pregnant or breastfeeding. However, the effects of taking melatonin beyond this period remain unclear due to limited research.

Growing Popularity Spurs Research Demand

As melatonin continues to grow in popularity and is currently the fourth most popular natural supplement among U.S. adults, researchers emphasize the importance of understanding its long-term impact on health.

The new study was presented at the American Heart Association's Scientific Sessions, underscoring the emerging interest in this issue within the medical community.

Related Insight

Previous research has also highlighted benefits of certain dietary supplements, such as one shown to reduce aggression by up to 28%, indicating the complex effects supplements can have on health.

Author’s Summary

Preliminary data link long-term melatonin use to increased heart failure risk, prompting a call for more comprehensive safety studies as this supplement’s popularity rises.

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ScienceAlert ScienceAlert — 2025-11-07